1-Benzoyl-3-[1-(3-nitrobenzyl)piperid-4-yl]urea → 1-Benzoyl-3-[1-(3-aminobenzyl)piperid-4-yl]urea

HRID 1284567Notes

Reaction equation

HRID 1284567 reaction equation
[C:1]([NH:9][C:10]([NH:12][CH:13]1[CH2:18][CH2:17][N:16]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([N+:26]([O-])=O)[CH:21]=2)[CH2:15][CH2:14]1)=[O:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>[Pd]>[C:1]([NH:9][C:10]([NH:12][CH:13]1[CH2:18][CH2:17][N:16]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([NH2:26])[CH:21]=2)[CH2:15][CH2:14]1)=[O:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 129423121-Benzoyl-3-[1-(3-nitrobenzyl)piperid-4-yl]ureaHCID 178418361HCID 178418361, compound

Product 1

HCID 129423061-Benzoyl-3-[1-(3-aminobenzyl)piperid-4-yl]ureaYield 46.1%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1-Benzoyl-3-[1-(3-nitrobenzyl)piperid-4-yl]urea 4.47 g (from Example 13) was hydrogenated with 5% Pd/C (0.5 g) at atmospheric pressure and room temperature until no more hydrogen was taken up. The catalyst was filtered and the filtrate evaporated. The residue was dissolved in water and basified with 0.880 ammonia. The precipitated solid was filtered, washed well with water, dried, treated with charcoal, and evaporated to give the title compound, (1.9 gms). This was recrystallised from ethanolic HCl to give the dihydrochloride salt, monohydrate, m.p. 194°-195° C.

Workup

  1. filtrationThe catalyst was filtered
  2. customthe filtrate evaporated
  3. dissolutionThe residue was dissolved in water and basified with 0.880 ammonia
  4. filtrationThe precipitated solid was filtered
  5. washwashed well with water
  6. customdried
  7. additiontreated with charcoal
  8. customevaporated

Sources & evidence

ORD record
ord-968ee0bd57814100957c24ce155d0081
Source dataset
uspto-grants-1986_01
Patent number
US04563466

Reaction notes

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