Calcium Hydroxide → HCID 131714487, compound

HRID 1284590Notes

Reaction equation

HRID 1284590 reaction equation
[CH2:1]([O:4][N:5]=[C:6]([C:29]1[N:33]=[C:32]([NH:34][P:35]([OH:38])([OH:37])=[O:36])[S:31][N:30]=1)[C:7]([NH:9][CH:10]1[C:27](=[O:28])[N:12]2[C:13]([C:24]([O-:26])=[O:25])=[C:14]([CH2:17][N+:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:15][S:16][C@H:11]12)=[O:8])[CH:2]=[CH2:3].[OH-].[Ca+2:40].[OH-]>O>[Ca:40].[CH2:1]([O:4][N:5]=[C:6]([C:29]1[N:33]=[C:32]([NH:34][P:35]([OH:37])([OH:38])=[O:36])[S:31][N:30]=1)[C:7]([NH:9][CH:10]1[C:27](=[O:28])[N:12]2[C:13]([C:24]([O-:26])=[O:25])=[C:14]([CH2:17][N+:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:15][S:16][C@H:11]12)=[O:8])[CH:2]=[CH2:3]

Participants

5

Reactant 2

HCID 6093208Calcium HydroxideHCID 131714487HCID 131714487, compound

Product 2

HCID 5460341CalciumHCID 131714487HCID 131714487, compoundYield 106.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of 7-[2-allyloxyimino-2-(5-phosphonoamino-1,2,4-thiadiazol-3-yl)acetamido]-3-(1-pyridiniomethyl)-3-cephem-4-carboxylate (syn isomer) (5.81 g) in water (150 ml) was adjusted to pH 6.0 with calcium hydroxide (760 mg). After a small amount of insoluble material was filtered off, the filtrate was lyophilized to give calcium salt of 7-[2-allyloxyimino-2-(5-phosphonoamino-1,2,4-thiadiazol-3-yl)acetamido]-3-(1-pyridiniomethyl)-3-cephem-4-carboxylate (syn isomer) (6.2 g), mp.>230° C.

Workup

  1. filtrationAfter a small amount of insoluble material was filtered off

Sources & evidence

ORD record
ord-e68e0afcd4654f8d8e52c85d1f0c5952
Source dataset
uspto-grants-1986_01
Patent number
US04563449

Reaction notes

Loading…