Hydrochloric Acid → N-(2-fluoro-5-aminophenyl)-3,4,5,6-tetrahydrophthalimide

Participants

Reaction Steps

The compound (VIII) is prepared by reacting the compound (VII), i.e. N-(2-fluoro-5-nitrophenyl)-3,4,5,6-tetrahydrophthalimide, with a 2 to 5 equivalent amount of iron powders (e.g. reduced iron, electrolytic iron) in a solvent in the presence of a catalytic amount of an acid (e.g. hydrochloric acid, sulfuric acid, acetic acid) at a temperature of 90° to 120° C. for a period of 1 to 10 hours.

Provenance & Evidence