Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl ester → 2-(2-Formamidothiazol-4-yl)-2-isopropoxyiminoacetic acid

HRID 1284678Notes

Reaction equation

HRID 1284678 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH:13]([CH3:15])[CH3:14])[C:8]([OH:10])=[O:9])[N:6]=1.C[C:17](OCC1C2C(=CC=CC=2)C(COC(C)=O)=C2C=1C=CC=C2)=[O:18]>C(O)=O>[CH:17]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH:13]([CH3:15])[CH3:14])[C:8]([OH:10])=[O:9])[N:6]=1)=[O:18]

Participants

4

Reactant 2

HCID 613145Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl esterHCID 541000552-Isopropoxyimino-2-(2-aminothiazol-4-yl)acetic acid

Product 1

HCID 538092752-(2-Formamidothiazol-4-yl)-2-isopropoxyiminoacetic acid

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

2-(2-Aminothiazol-4-yl)-2-iso-propoxyiminoacetic acid (syn isomer, 4 g.), acetic anhyddride (7.6 g.) and formic acid (3.4 g.) were treated in a similar manner to that of Example F-(5) to give 2-(2-formamidothiazol-4-yl)-2-isopropoxyiminoacetic acid (syn isomer, 3.75 g.), mp. 168° to 169° C. (dec.).

Sources & evidence

ORD record
ord-2327265e369b4652983b49ef7cb1bbcf
Source dataset
uspto-grants-1986_01
Patent number
US04563522

Reaction notes

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