Acetic Anhydride → 2-(2-Formamidothiazol-4-yl)-2-isobutoxyiminoacetic acid

HRID 1284688Notes

Reaction equation

HRID 1284688 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH2:13][CH:14]([CH3:16])[CH3:15])[C:8]([OH:10])=[O:9])[N:6]=1.[C:17](OC(=O)C)(=[O:19])C>C(O)=O>[CH:17]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH2:13][CH:14]([CH3:16])[CH3:15])[C:8]([OH:10])=[O:9])[N:6]=1)=[O:19]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 539681782-(2-Aminothiazol-4-yl)-2-isobutoxyiminoacetic acid

Product 1

HCID 539625342-(2-Formamidothiazol-4-yl)-2-isobutoxyiminoacetic acidYield 86.9%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

2-(2-Aminothiazol-4-yl)-2-iso-butoxyiminoacetic acid (syn isomer, 11.5 g.), acetic anhydride (19.3 g.) and formic acid (8.7 g.) were treated in a similar manner to that of Example F-(5) to give 2-(2-formamidothiazol-4-yl)-2-iso-butoxyiminoacetic acid (syn isomer, 11.15 g.), mp 163° C. (dec.).

Sources & evidence

ORD record
ord-85a88387591c481a94477c0655904d70
Source dataset
uspto-grants-1986_01
Patent number
US04563522

Reaction notes

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