HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 2-(2-aminothiazol-4-yl)-2-cyclohexyloxyiminoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Ethyl 4-chloro-2-[(cyclohexyloxy)imino]-3-oxobutanoate | HCID 53775948 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-(2-aminothiazol-4-yl)-2-cyclohexyloxyiminoacetate | HCID 53692631 | 12% |
Reaction Steps
Ethyl 4-chloro-2-cyclohexyloxyimino-3-oxobutyrate (syn isomer, 27.8 g.), thiourea (7.7 g.), sodium acetate 3-hydrate (13.7 g.), water (70 ml.) and ethanol (140 ml.) were treated in a similar manner to that of Example F-(3) to give ethyl 2-(2-aminothiazol-4-yl)-2-cyclohexyloxyiminoacetate (syn isomer, 3.6 g.), mp. 125° to 126° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04563522 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-34972a56fa1646c9be2a537884ed2b5b |
| Source note | uspto-grants-1986_01 |