HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 2-(2-aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Sodium Acetate Trihydrate | HCID 23665404 | — |
| Reactant | Ethyl 2-(2-chloroethoxyimino)-3-oxo-4-chlorobutyrate | HCID 54169228 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 2-(2-aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetate | HCID 53650816 | 45.7% |
Reaction Steps
Ethyl 2-(2-chloroethoxyimino)-3-oxo-4-chlorobutyrate (syn isomer, 68 g.), thiourea (20.2 g.), sodium acetate trihydrate (36.2 g.), ethanol (270 ml.) and water (170 ml.) were treated in a similar manner to that of Example F-(3) to give ethyl 2-(2-aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetate (syn isomer, 33.7 g.), mp 126° to 128° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04563522 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-b63f497aa5d84f67b8a90e1be0e33e52 |
| Source note | uspto-grants-1986_01 |