HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-[2-(2-Aminothiazol-4-yl)-2(2,2,2-trifluoroethoxyimino)acetamido]-3-cephem-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 7-[2-(2-Formamidothiazol-4-yl)-2-(2,2,2-trifluoroethoxyimino)acetamido]-3-cephem-4-carboxylic acid | HCID 131712480 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-[2-(2-Aminothiazol-4-yl)-2(2,2,2-trifluoroethoxyimino)acetamido]-3-cephem-4-carboxylic acid | HCID 131712481 | 77.9% |
Reaction Steps
A suspension of 7-[2-(2-formamidothiazol-4-yl)-2-(2,2,2-trifluoroethoxyimino)acetamido]-3-cephem-4-carboxylic acid (syn isomer, 1.5 g.), conc. hydrochloric acid (1.3 ml.), tetrahydrofuran (10 ml.) and methanol (30 ml.) was treated in a similar manner to that of Example 21-(3) to give 7-[2-(2-aminothiazol-4-yl)-2-(2,2,2-trifluoroethoxyimino)acetamido]-3-cephem-4-carboxylic acid (syn isomer, 1.1 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04563522 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-58fe48d5e6ef4885a1a4e0ae733ca92f |
| Source note | uspto-grants-1986_01 |