Acetyl chloride → N-acetyl-N-propargyl-2,4-dimethyl-5-(N-acetyl-N-trifluormethanesulfonylamino)benzenesulfonamide

Participants

Reaction Steps

To a solution of N-propargyl-2,4-dimethyl-5-(trifluoromethanesulfonamido)benzenesulfonamide (1.5 g) and triethylamine (1.2 g) in tetrahydrofuran (20 ml), acetyl chloride (1.0 g) was added, and the resultant mixture was allowed to stand at room temperature overnight. The reaction mixture was concentrated, admixed with 5% hydrochloric acid and extracted with chloroform. The extract was concentrated to give an oily substance, which was purified by silica gel chromatography to give 1.4 g of N-acetyl-N-propargyl-2,4-dimethyl-5-(N-acetyl-N-trifluoromethanesulfonylamino)benzenesulfonamide (Compound No. 10). nD20 1.5209.

Provenance & Evidence