Allyl bromide → HCID 13321945, compound

Participants

Reaction Steps

Under argon, 0.4 g of 8-amino-5H-pyrimido[5,4-b]indole-2-carboxylic acid ethyl ester (Example 11) is agitated in 8 ml of ethanol with 0.16 ml of diazabicycloundecane and 0.25 ml of allyl bromide for 5 hours at 50°-60° C. The reaction solution is subsequently evaporated, and the residue is taken up in ethyl acetate. This solution is washed first with water, then with sodium bicarbonate solution, and finally again with water, dried with sodium sulfate, and concentrated, thus obtaining 0.18 g of 8-diallylamino-5H-pyrimido[5,4-b]indole-2-carboxylic acid ethyl ester, mp 188°-190° C.

Provenance & Evidence