Tetrahydrofuran → HCID 54006151, compound

Participants

Reaction Steps

A suspension of 150 mg of 8-chlorocarbonyl-5H-pyrimido[5,4-b]indole-2-carboxylic acid ethyl ester (Example 19) in 5 ml of tetrahydrofuran is combined with a solution of triethylamine in ethanol at 4° C. until a pH of 8 is attained. The mixture is then stirred for 2 hours at room temperature and evaporated. After distribution in ethyl acetate/dilute ammonia solution, the organic phase is separated, dried, filtered, and concentrated. After chromatography over silica gel with methylene chloride/ethanol=10:1 as the eluent, 70 mg of 8-ethoxycarbonyl-5H-pyrimido[5,4-b]indole-2-carboxylic acid ethyl ester is obtained.

Provenance & Evidence