1H-1,2,4-Triazole → alpha-((4-Chlorophenoxy)methyl)-alpha-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol

Participants

Reaction Steps

72.15 g (0.3 mol) of 2-(4-chlorophenoxymethyl)-2-tert.-butyloxirane and 24.15 g (0.35 mol) of 1,2,4-triazole in 120 ml of ethanol are heated under reflux for 48 hours. The mixture is then evaporated and the residue is taken up in 200 ml of ethyl acetate and heated. It is then cooled in an ice bath and the solid material is filtered off with suction and washed with ethyl acetate. The filtrate is evaporated, the residue is dissolved in ether/hexane and hydrogen chloride is passed through. The precipitate is filtered off with suction, washed with ether and the free base is obtained by addition of ethyl acetate/1 N sodium hydroxide solution. 60.2 g (65% of theory) of 2-(4-chlorophenoxymethyl)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanol of melting point 84° to 87° C. are obtained.

Provenance & Evidence