o-(Trifluoromethyl)benzaldehyde → HCID 20250823, compound

Participants

Reaction Steps

13.2 Grams of o-trifluoromethylbenzaldehyde, 14.6 g of 4-chlorobutyl acetoacetate and 8.8 g of methyl 3-aminocrotonate were added to 50 ml of isopropanol, and the whole mixture was refluxed by heating for 4 hours. The reaction mixture was concentrated, and the residue was purified by a silica gel column chromatography (eluant=chloroform) to yield 18.2 g of 4-chlorobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-trifluoromethylphenyl)pyridine-3,5-dicarboxylate in the form of yellow oily substance.

Provenance & Evidence