Sulfuric Acid → HCID 13491592, compound

Participants

Reaction Conditions

Reaction Steps

17.5 g (0.0566 mol) of N-methyl-4-phenyl-8-(hydroxyiminoacetylamino)isoquinoline were added in small portions to 43.75 ml of concentrated H2SO4 at 45° C. and the mixture was warmed at 45° C. for 75 minutes. It was cooled to room temperature and poured onto 450 g of ice. A pH of 6.8 was then established with 2N NaOH. The precipitate which had separated out was filtered off with suction and washed with water. After drying, 15.3 g (92.5% of theory) of orange-colored crude product are obtained. (Melting point of the pure product=about 188° C., decomposition).

Provenance & Evidence