反应详情

A portion of the (-)-2-amino-1-butanol D-(-)-mandelate wet cake 155 grams "as is"--90.3% pure; 0.58 mole) from resolution A is dissolved in the mother liquor plus water washes from (D) at 50°-55° C. and the solution is distilled under vacuum to remove 41 mls of methanol and water. The concentrated solution is then treated with 37% hydrochloric acid (60 mls) and processed as described in (D) to obtain 77 grams of D-(-)-mandelic acid (87.4% of theoretical; m.p. 130°-132° C.; [α]D25° =-152.9° (C=2, H2O)).

1. distillationthe solution is distilled under vacuum
2. customto remove 41 mls of methanol and water
3. additionThe concentrated solution is then treated with 37% hydrochloric acid (60 mls)