Ethyl isocyanate → N-Bicyclo[2.2.1]heptan-2-yl-N-[(4-chlorophenyl)methyl]-N'-ethylurea

Participants

Reaction Steps

24 g of N-4-chlorobenzyl-2-norbornylamine was dissolved in 400 ml of hexane, and with stirring and cooling, a solution of 8 g of ethyl isocyanate in 30 ml of hexane was added dropwise to the solution. After the addition, the temperature of the mixture was gradually raised, and it was stirred for about 3 hours at 40° C. After cooling, the precipitated crystals were suction-filtered, and recrystallized from a mixture of hexane and ethanol to give 26.7 g of the desired 1-(4-chlorobenzyl)-3-ethyl-1-(2-norbornyl)urea. mp. 132°-133° C.

Provenance & Evidence