Oxalyl chloride → 2,6-Difluorobenzoyl isocyanate

Participants

Reaction Conditions

Reaction Steps

In 150 ml of dichloroethane was suspended 13.5 g of 2,6-difluorobenzamide, and 14.0 g of oxalyl chloride was little by little added to the suspension, followed by heating under reflux at about 110° C. for 15 hours. The reaction mixture was concentrated under reduced pressure, and the resultant oily substance was distilled under reduced pressure to give 12 g of the subject compound as an oily material of boiling point of 123° C./60 mmHg.

Provenance & Evidence