HCID 13454546, compound → HCID 13375120, compound

HRID 1284941Notes

Reaction equation

HRID 1284941 reaction equation
C(OCC)(=O)C.[ClH:7].[CH2:8]([O:10][C:11]([C@H:13]([NH:22][C@@H:23]1[C:29](=[O:30])[N:28]([CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])[C:27]2[CH:39]=[CH:40][CH:41]=[CH:42][C:26]=2[S:25][CH2:24]1)[CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:12])[CH3:9]>CCOCC>[ClH:7].[CH2:8]([O:10][C:11]([C@H:13]([NH:22][C@@H:23]1[C:29](=[O:30])[N:28]([CH2:31][C:32]([OH:34])=[O:33])[C:27]2[CH:39]=[CH:40][CH:41]=[CH:42][C:26]=2[S:25][CH2:24]1)[CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:12])[CH3:9]

Participants

4

Reactant 2

HCID 13454546HCID 13454546, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 13375120HCID 13375120, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 5 ml of 5N hydrogen chloride-ethyl acetate solution and 0.5 g of tert-butyl 3(R)-[1(R)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate obtained in Example 1 is allowed to stand at room temperature overnight. Twenty ml of ether and 100 ml of petroleum ether are added to the mixture to deposit colorless powder, which is collected by filtration to give 0.42 g of 3(R)-[1(R)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride.

Workup

  1. filtrationis collected by filtration

Sources & evidence

ORD record
ord-b391b5c9981444a694c7e532a3b38080
Source dataset
uspto-grants-1986_01
Patent number
US04564612

Reaction notes

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