Sodium Hydroxide → HCID 13454594, compound

Participants

Reaction Steps

In 2 ml of methanol are dissolved 0.1 g of 3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride and 1.5 ml of 1N aqueous sodium hydroxide. The solution is allowed to stand at room temperature for 2 hours, concentrated to about 1 ml at a temperature of not higher than 40° C. under reduced pressure, and acidified slightly with 1N hydrochloric acid to give 0.067 g of 3(R)-[1(S)-carboxy-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid as colorless prisms, m.p. 207°-210° C.

Provenance & Evidence