Acetic Acid Mixture with Hydrobromic Acid → HCID 70417183, compound

Participants

Reaction Steps

To a solution of 3(R)-(5-benzyloxycarbonylamino-1-carboxypentyl)amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid (40 mg) obtained in Example 52-(2) in acetic acid (1 ml) is added 30% hydrogen bromide-acetic acid solution (1 ml). The resulting mixture is allowed to stand for 1 hour at room temperature and diluted with a mixture ethyl ether (80 ml) and petroleum ether (20 ml), followed by stirring. The supernatant layer is removed by decantation, and precipitate is collected and dried to provide 3(R)-(5-amino-1-carboxypentyl)amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid dihydrobromide (33 mg) as colorless powder.

Provenance & Evidence