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Thionyl Chloride → 2-[[4-[4-(Trifluoromethoxy)phenoxy]phenoxy]]propanoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | HCID 23469824 | HCID 23469824 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-[[4-[4-(Trifluoromethoxy)phenoxy]phenoxy]]propanoyl chloride | HCID 23469823 | — |
反応手順
To 17.11 g. (0.05 mole) of 2-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoic acid is added 1 ml. of DMF, followed by 50 ml. of thionyl chloride. After evolution of HCl ceases, the thionyl chloride excess is removed in vacuum. The residue is extracted with methylene chloride and the methylene chloride solution washed with ice water, dried, and the solvent removed, leaving 2-[[4-[4-(trifluoromethoxy)phenoxy]-phenoxy]]propanoyl chloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04259532 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-f45e87b23fb34b9daf983d84e798b337 |
| 出典メモ | uspto-grants-1981_03 |