Acetic Acid → HCID 13454632, compound

Participants

Reaction Steps

A solution of 3(R)-[10-amino-1(S)-ethoxycarboxyldecyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid (0.28 g) obtained in Example 74 in 1N sodium hydroxide (7 ml) stands for 1 hour at room temperature. After addition of acetic acid (2 ml) and water (5 ml), the mixture is subjected to Amberlite XAD-2 column chromatography (methanol:water=1:1). The eluate is concentrated under reduced pressure. The deposited crystal is collected by filtration and dried to yield 3(R)-[10-amino-1(S)-carboxydecyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid (0.12 g).

Provenance & Evidence