Water → HCID 13306691, compound

HRID 1284978Notes

Reaction equation

HRID 1284978 reaction equation
[NH2:1][C:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[N:3]=1.[C:17](OC(=O)C)(=[O:19])C.O>C(O)=O>[CH:17]([NH:1][C:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:14])([F:16])[F:15])[CH:8]=2)[N:3]=1)=[O:19]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 477954,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine

Product 1

HCID 13306691HCID 13306691, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

3-Amino-1-(3-trifluoromethylphenyl)-2-pyrazoline (1.907 g) was dissolved in formic acid (20 ml). The solution was stirred at 60° and acetic anhydride (2.4 ml) was added dropwise. The mixture was heated for 1 hour at 60° and then poured into water and stirred to decompose the residual excess anhydride. 3-Formamido-1-(3-trifluoromethylphenyl)-2-pyrazoline resulted as a crystalline solid m.p. 128°-129°. This compound was then used to prepare the compound of Example 1, as hereinbefore described.

Workup

  1. temperatureThe mixture was heated for 1 hour at 60°
  2. stirringstirred

Sources & evidence

ORD record
ord-2d62e4bde4bb4fef899a7e5f26bcd142
Source dataset
uspto-grants-1986_01
Patent number
US04564684

Reaction notes

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