Acetic Anhydride → HCID 20251290, compound

HRID 1284979Notes

Reaction equation

HRID 1284979 reaction equation
[NH2:1][C:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[N:3]=1.[C:13](OC(=O)C)(=[O:15])C>C(O)=O>[CH:13]([NH:1][C:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[N:3]=1)=[O:15]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 134966252-(3-Amino-2-pyrazolin-1-yl)pyridine

Product 1

HCID 20251290HCID 20251290, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

3-Amino-1-(2-pyridyl)-2-pyrazoline (1.5 g) was added to formic acid (22 ml) at 60° in an atmosphere of nitrogen. The mixture was stirred whilst acetic anhydride (2.3 ml) was added dropwise. The mixture was heated at 100° for 1 hour before being evaporated in vacuo to give 3-formamido-1-(2-pyridyl)-2-pyrazoline which was recrystallised from isopropanol, m.p. 182°-183° (yield 1.17 g).

Workup

  1. additionwas added dropwise
  2. temperatureThe mixture was heated at 100° for 1 hour
  3. custombefore being evaporated in vacuo

Sources & evidence

ORD record
ord-b920c6475c2f4beb9ba969d226be3fd2
Source dataset
uspto-grants-1986_01
Patent number
US04564684

Reaction notes

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