HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-chloroacetoacetate → Ethyl 4-ethoxy-3-oxobutyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-chloroacetoacetate | HCID 69484 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 4-ethoxy-3-oxobutyrate | HCID 3016245 | 90.4% |
Reaction Steps
Using the method described in Example 1, 108.6 g of 4-chloroacetoacetic acid ethyl ester in 143 g of acetonitrile was reacted with 103.6 g of sodium ethylate. 4-ethoxyacetoacetic acid ethyl ester was obtained in a yield of 90.4 percent, related to the amount of 4-chloroacetoacetic acid ethyl ester used. The purity of the product was 98.5 percent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04564696 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-69497f0993274c4eb908dcf6b6e051e5 |
| Source note | uspto-grants-1986_01 |