HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine → 5-Diethylamino-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 25013543 | — |
| Product | 5-Diethylamino-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 25014248 | — |
Reaction Steps
Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 88 mg; 0.30 mmol) and diethylamine (0.32 mL; 3.1 mmol) under microwave irradiation according to the procedure described for Example 14 provided after purification by reverse phase HPLC, 5-diethylamino-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (16 mg, 16%) as an off-white powder. ES-MS m/e calcd for C19H31N4O (M+H+) 331, found 331.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728029B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-deb484043d9b43fdb95c008e96681372 |
| Source note | uspto-grants-2010_06 |