HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → [4-(Dimethylamino)phenyl](4-hydroxyphenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Methanone, [4-(dimethylamino)phenyl](4-methoxyphenyl)- | HCID 2825054 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | [4-(Dimethylamino)phenyl](4-hydroxyphenyl)methanone | HCID 14205141 | 77.2% |
Reaction Steps
A solution of 10.0 g 1-[4-(dimethylamino)phenyl]-1-(4-methoxyphenyl)-methanone in 30 ml 48% hydrobromic acid was heated at reflux for 21 hours. The reaction mixture was poured into aqueous sodium bicarbonate and the precipitate filtered. Recrystallization from 150 ml of methanol gave 7.3 g of white solid, m.p. 199°-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04565769 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-1aaa15cf302240d98408003d7af085b3 |
| Source note | uspto-grants-1986_01 |