Water → HCID 15475793, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 12.0 g of 1-[4-(dimethylamino)phenyl]-1-[4-hydroxyphenyl)-methanone and 2.2 g sodium hydroxide in 120 ml dimethylformamide was heated at 90° C. until all the sodium hydroxide had dissolved. 6.9 g 2-bromoethanol was added and the reaction heated at about 105° C. for 24 hours. The reaction mixture was poured into water and the product isolated by extraction with methylene chloride to yield 7.7 g, m.p. 142°-143° C., λmax (chloroform) 348 nm (ε=26,400), 271 nm (ε=12,500), 255 nm (ε=11,900 nm).

Provenance & Evidence