HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-nitropyridin-4-amine → 1-(4-Fluorophenyl)-4-[4-(4,5-diamino-pyridin-2-yl)-1-piperazinyl]-1-butanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-nitropyridin-4-amine | HCID 10910058 | — |
| Reactant | 1-(4-Fluorophenyl)-4-[4-(4-amino-5-nitro-pyridin-2-yl)-1-piperazinyl]-1-butanone | HCID 20211983 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-(4-Fluorophenyl)-4-[4-(4,5-diamino-pyridin-2-yl)-1-piperazinyl]-1-butanone | HCID 20211986 | — |
Reaction Steps
The starting material may be prepared as described in Example 1 starting from 4-amino-2-chloro-5-nitro-pyridine via 1-(4-fluorophenyl)-4-[4-(4-amino-5-nitro-pyridin-2-yl)-1-piperazinyl]-1-butanone to give 1-(4-fluorophenyl)-4-[4-(4,5-diamino-pyridin-2-yl)-1-piperazinyl]-1-butanone, m.p. 166°-169° (from ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04565816 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-028ce95a888a4cb8b9988bf483b9ae06 |
| Source note | uspto-grants-1986_01 |