Sodium Hydroxide → HCID 178432319, compound

Participants

Reaction Steps

5 g 4-[4-(4,5-Diacetylamino-2-pyridinyl)-1-piperazinyl]-1-(4-fluorophenyl)-1-butanone and 25 g polyphosphoric acid are stirred and heated 1 hour at 140°. The reaction mixture is then cooled to room temperature, treated with 200 ml water, made alkaline with aqueous NaOH solution and extracted with methylene chloride. The extract is dried and evaporated. The residue is recrystallized from dichlormethane/diisopropylether to give the title compound, m.p. 180°-183°. M.p. of the bis-maleate 172°-173.5°.

Provenance & Evidence