化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl Acetate → Chinoin 170
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 2-(Theophyllin-7-yl)-acetamidoxime | HCID 3057490 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Chinoin 170 | HCID 139570 | 87% |
反応手順
5.04 g. of 2-(theophyllin-7-yl)-acetamidoxime, 2.16 g. of sodium methylate and 10 cm3 ethyl acetate are heated under shaking and under pressure in 150 cm3 methanol at 100° C. for 8.5 hours. After processing 4.8 g. (87% yield) of 7-[(5-methyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline are obtained. M.p.: 135°-136° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04565817 |
| 出典データセット | uspto-grants-1986_01 |
| ORD ID | ord-9880b85227844ad3b713d627f97bb011 |
| 出典メモ | uspto-grants-1986_01 |