Glycine, N,N-diethyl-, ethyl ester → 7-[(5-Diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline

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Reaction Steps

5.04 g. of 2-(theophyllin-7-yl)-acetamidoxime, 2.16 g. of sodium methylate, 6.37 g. of diethylamino acetic acid ethylester and 80 cm3 methanol are stirred for 10 hours at 100° C. in a closed system under pressure. 5.2 g. (80% yield) of 7-[(5-diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline are obtained. m.p.: 69°-70° C. (cyclohexane).

Provenance & Evidence