HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Carbonate → HCID 178481349, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Carbonate | HCID 7766 | — |
| Reactant | 2-(Theophyllin-7-yl)-acetamidoxime | HCID 3057490 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 178481349 | HCID 178481349 | 82% |
Reaction Steps
5.04 g. of 2-(theophylline-7-yl)-acetamidoxime, 2.16 g. of sodium methylate, 4.72 g. of diethyl carbonate and 100 cm3 of toluene are heated for 2 hours to boiling, the mixture is then evaporated and the residue crystallized from water. 4.3 g. (82% yield) of 7-[(5-hydroxy-1,2,4-oxadiazol-3-yl)-methyl]-theophylline are obtained. M.p.: 206°-207° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04565817 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-9f774ce5b3ef4a46ab30b25d3f122b4c |
| Source note | uspto-grants-1986_01 |