Oxalyl chloride → (S)-N-(2-naphthalenesulfonyl)prolyl chloride

Participants

Reaction Steps

15.6 g of (S)-1-(2-naphthylsulfonyl)pyrrolidine-2-carboxylic acid [Chem, Ber., 35, 3783 (1902)] are dissolved in 120 ml of anhydrous benzene, and 17.5 ml of oxalyl dichloride are added dropwise thereto under stirring. The mixture is allowed to stand at 40° to 50° C. overnight. Then, the mixture is condensed to dryness under reduced pressure, and the residue is recrystallized from a mixture of n-hexane and benzene. 14.3 g of (S)-1-(2-naphthylsulfonyl)pyrrolidine-2-carbonyl chloride are obtained.

Provenance & Evidence