Hydrochloric Acid → HCID 12858247, compound

Participants

Reaction Steps

Sodium hydride (0.34 g; 14.16 mmol) was added to a stirred solution of diphenylphosphine oxide (2.8 g; 13.86 mmol) in dimethylformamide (30 ml) at room temperature under argon. To the yellow solution was then added cyclohexane epoxide (0.68 g; 6.94 mmol) and the reaction mixture was warmed to 70° C. The yellow color slowly faded and after 2 hours a white precipitate had formed. The mixture was cooled, acidified with dilute HCl and the product extracted with chloroform. The removal of all solvents afforded, after recrystallization from chloroformdiethylether, trans-1,2-bis(diphenylphosphinyl)cyclohexane (3.10 g; 93% yield).

Provenance & Evidence