1-Bromo-5-[2-n-propyl-3-hydroxy-4-acetylphenoxy]-pentane → 2-Carbomethoxy-7-[5-(2-n-propyl-3-hydroxy-4-acetylphenoxy)pentoxy]-8-n-propylchromone

HRID 1285246Notes

Reaction equation

HRID 1285246 reaction equation
[C:1]([C:5]1[O:6][C:7]2[C:12]([C:13](=[O:15])[CH:14]=1)=[CH:11][CH:10]=[C:9]([OH:16])[C:8]=2[CH2:17][CH2:18][CH3:19])([O:3][CH3:4])=[O:2].[CH2:20]([C:23]1[C:35]([OH:36])=[C:34]([C:37](=[O:39])[CH3:38])[CH:33]=[CH:32][C:24]=1[O:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]Br)[CH2:21][CH3:22]>>[C:1]([C:5]1[O:6][C:7]2[C:12]([C:13](=[O:15])[CH:14]=1)=[CH:11][CH:10]=[C:9]([O:16][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][O:25][C:24]1[CH:32]=[CH:33][C:34]([C:37](=[O:39])[CH3:38])=[C:35]([OH:36])[C:23]=1[CH2:20][CH2:21][CH3:22])[C:8]=2[CH2:17][CH2:18][CH3:19])([O:3][CH3:4])=[O:2]

Participants

3

Reactant 2

HCID 137632981-Bromo-5-[2-n-propyl-3-hydroxy-4-acetylphenoxy]-pentaneHCID 139207782-Carbomethoxy-7-hydroxy-8-propylchromone

Product 1

HCID 135378622-Carbomethoxy-7-[5-(2-n-propyl-3-hydroxy-4-acetylphenoxy)pentoxy]-8-n-propylchromoneYield 66.7%

Procedure

Using the procedure of Example 2, 5.25 g (20 mmoles) of 2-carbomethoxy-7-hydroxy-8-propylchromone and 8.24 g (24 mmoles) of 5-(2-n-propyl-3-hydroxy-4-acetylphenoxy)-1-bromopentane gave 7.0 g (66%) of the title compound, mp 86°-87° C. Calc: C, 68.69; H, 6.92; Found: C, 68.80; H, 6.89.

Sources & evidence

ORD record
ord-eeabdf5a87484755beecf52395b02b4e
Source dataset
uspto-grants-1986_01
Patent number
US04565882

Reaction notes

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