反应详情

5.25 (10 mmole) of the compound from Example 5, was dissolved in 125 ml of glacial acetic acid and 0.5 g of 5% palladium on carbon added. The resulting suspension was hydrogenated at 70° C. and 50 psi for two hours. The reaction mixture was cooled and filtered to remove catalyst. After removing the solvent by rotary evaporation, the residue was purified by high pressure liquid chromatography to furnish 1.76 g (35%) of the title compound as an oil. Calc: C, 72.26; H, 8.49; Found: C, 72.20; H, 8.59.

1. customwas hydrogenated at 70° C.
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. customto remove catalyst
5. customAfter removing the solvent
6. customby rotary evaporation
7. customthe residue was purified by high pressure liquid chromatography