Cyclopropylamine → HCID 178471889, compound

HRID 128526Notes

Reaction equation

HRID 128526 reaction equation
[Cl:1][C:2]1[C:19]([F:20])=[C:18]([F:21])[C:17]([Cl:22])=[C:16]([F:23])[C:3]=1[C:4]([C:6](=[CH:12]OCC)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].[CH:24]1([NH2:27])[CH2:26][CH2:25]1>C(O)C>[Cl:1][C:2]1[C:19]([F:20])=[C:18]([F:21])[C:17]([Cl:22])=[C:16]([F:23])[C:3]=1[C:4]([C:6](=[CH:12][NH:27][CH:24]1[CH2:26][CH2:25]1)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 53922423HCID 53922423, compound

Product 1

HCID 178471889HCID 178471889, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

37.1 g (0.1 mol) of ethyl 2-(2,5-dichloro-3,4,6-trifluorobenzoyl)-3-ethoxyacrylate are initially introduced into the reaction vessel in 100 ml of ethanol. 6.8 g (0.12 mol) of cyclopropylamine, dissolved in 10 ml of ethanol, are added dropwise. The mixture is then stirred at room temperature for 4 hours. The precipitate is filtered off with suction, washed with petroleum ether and dried in air.

Workup

  1. additionare added dropwise
  2. filtrationThe precipitate is filtered off with suction
  3. washwashed with petroleum ether
  4. customdried in air

Sources & evidence

ORD record
ord-917b62b121f94340b17bb350d6760aee
Source dataset
uspto-grants-1995_11
Patent number
US05464796

Reaction notes

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