反应详情

920 mg (2.41 mmole) of the compound from Example 38 was dissolved in 50 ml methanol and 92 mg 5% palladium on carbon added. The suspension was hydrogenated at room temperature and 2 psi for 2.5 hours. Removal of the catalyst by filtration and removal of methanol by rotary evaporation gave 640 mg (91%) of the title compound as a light orange oil, which began to crystallize on standing, homogeneous by thin layer chromatography in 20% ethyl acetate-hexane.

1. customwas hydrogenated at room temperature
2. customRemoval of the catalyst
3. filtrationby filtration and removal of methanol
4. customby rotary evaporation