Sodium Bicarbonate → HCID 13188510, compound

Participants

Reaction Conditions

Reaction Steps

15.3 g of sodium bicarbonate were added to a solution, in 250 ml of tetrahydrofuran, of 36 g of the 1-(4-methylphenyl)-3-(4-aminophenyl)-n-propan-1-one prepared as described in Example A, and 18.5 g of N-methyl-N-methoxycarbamyl chloride were added dropwise at 10°-15° C., while cooling with ice. The mixture was stirred for 6 hours at 25° C., after which it was filtered and the filtrate was evaporated down under reduced pressure. The oil obtained crystallized after trituration with diisopropyl ether, and 38.5 g (79% of theory) of product of melting point 73°-74° C. were obtained.

Provenance & Evidence