Potassium Bicarbonate → HCID 53908225, compound

Participants

Reaction Steps

Under argon, 4.0 g of 21-bromo-17-formyloxy-1,4-pregnadiene-3,20-dione is agitated in a mixture of 150 ml of methanol and 24 ml of water with 1.3 g of potassium bicarbonate at room temperature. After one hour, the reaction mixture is introduced into ice water, the precipitated product is suctioned off, dissolved in ethyl acetate, washed with water, and dried over sodium sulfate, yielding 3.2 g of 21-bromo-17-hydroxy-1,4-pregnadiene-3,20-dione, mp 189.9° C. (decomposition).

Provenance & Evidence