Dichloromethane → HCID 13578829, compound

Participants

Reaction Steps

A mixture of 16-(phenylsulfinylmethyl)pregn-4,9(11),16-triene-3,20-dione (VIA, Example 14, 100 mg) in toluene (1 ml) and methanol (0.14 ml) containing 53 μl of trimethylphosphite was heated for 16 hrs at 65° in a sealed vial. TLC showed the reaction to be complete. Methylene chloride was added, the reaction mixture washed with water, the organic phase separated, dried and concentrated under reduced pressure to give the title compound. NMR (CDCl3) 0.77, 1.35, 2.31, 5.10, 5.27, 5.57 and 5.75 δ.

Provenance & Evidence