Methyl iodide → HCID 20248961, compound

HRID 1285334Notes

Reaction equation

HRID 1285334 reaction equation
[CH2:1]([N:8]1[CH2:14][C:12](=[O:13])[NH:11][C:9]1=[S:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:15][CH3:16]>CO>[IH:15].[CH2:1]([N:8]1[CH2:14][C:12](=[O:13])[N:11]=[C:9]1[S:10][CH3:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 53685104-Imidazolidinone, 1-(phenylmethyl)-2-thioxo-

Product 1

HCID 20248961HCID 20248961, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-Benzyl-2-thiohydantoin (8.07 g), iodomethane (10 ml) and methanol (50 ml) were warmed at 40°-42° C. for 8 hours. The reaction mixture was evaporated under reduced pressure, the residue was washed with diethyl ether and recrystallised from methanol-ethanol to give 1-benzyl-2-methylthio-2-imidazolin-4-one hydroiodide (4.86 g) m.p. 185°-190° C., as an impure light-buff coloured solid which was taken on to the next stage.

Workup

  1. customThe reaction mixture was evaporated under reduced pressure
  2. washthe residue was washed with diethyl ether
  3. customrecrystallised from methanol-ethanol

Sources & evidence

ORD record
ord-323d82de3baf487685aa77e1d8b8ca82
Source dataset
uspto-grants-1986_01
Patent number
US04567176

Reaction notes

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