4-Amino-1-methylpiperidine → HCID 9798459, compound

Participants

Reaction Conditions

Reaction Steps

A quantity of 3.5 gm (0.022 mol) of N,N'-carbonyldiimidazole is added to a suspension of 5 gm (0.02 mol) of 5,11-dihydro-6-oxo-6H-dibenz[b,e]azepin-11-carboxylic acid in 100 ml of tetrahydrofuran, and the mixture is heated to 40° C. for 30 minutes. Then, 2.5 gm (0.022 mol) of 4-amino-1-methylpiperidine are added, and the mixture is heated for a further two hours at 40° C. After cooling, the solvent is removed in vacuo, and the residue is purified by column chromatography on silica gel [ethylene chloride/methanol (9:1)]. Subsequently, 4.8 gm (68%) of the desired compound, M.p.: 230°-231° C., are obtained from the eluate. According to the mixed melting point, thin layer chromatography, and IR spectrum, the substance is identical to the product obtained in Example 3.

Provenance & Evidence