Sodium Hydroxide → HCID 178432636, compound

HRID 1285339Notes

Reaction equation

HRID 1285339 reaction equation
Br.Br.[NH:3]([C:7]1[S:8][CH:9]=[C:10]([C:12]2[N:13]=[C:14]([CH3:17])[NH:15][CH:16]=2)[N:11]=1)[C:4]([NH2:6])=[NH:5].[OH-].[Na+]>O>[NH:3]([C:7]1[S:8][CH:9]=[C:10]([C:12]2[N:13]=[C:14]([CH3:17])[NH:15][CH:16]=2)[N:11]=1)[C:4]([NH2:6])=[NH:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178419244HCID 178419244, compound

Product 1

HCID 178432636HCID 178432636, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Guanidino-4-(2-methyl-4-imidazolyl)thiazole dihydrobromide (13.4 g) was stirred with 66.9 ml H2O and the pH slowly adjusted to a stable value of 10.0 over 2 hours with 22.6 ml of 3N NaOH while maintaining a temperature of 22°-24° C. Title product was recovered by suction filtration with water wash, pulled to a tight cake under a rubber dam, repulped in 28 ml acetone for 2 hours, refiltered, washed with 12 ml acetone and dried at 40° C. in vacuum to yield crystalline title product, 8.66 g, containing about 15% water.

Workup

  1. temperaturewhile maintaining a temperature of 22°-24° C
  2. filtrationTitle product was recovered by suction filtration with water
  3. washwash
  4. washwashed with 12 ml acetone
  5. customdried at 40° C. in vacuum

Sources & evidence

ORD record
ord-d8d2fffe8763459d8f17a33620bbcb49
Source dataset
uspto-grants-1986_01
Patent number
US04567179

Reaction notes

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