Sodium Bicarbonate → 2-Cyano 3-(2,6-dichlorophenyl)propanoic acid

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Reaction Conditions

Reaction Steps

92 g of 2-cyano 3-(2,6-dichlorophenyl)propenoic acid (Tetrahedron Lett., 1975, p.3643-4) are put into 860 ml of methanol and 285 ml of a 10% sodium hydrogen carbonate solution. This is cooled to 18° C. and the necessary quantity of sodium borohydride is introduced over a two and one-half hour period. The mixture is left for 2 hours at ambient temperature, then concentrated and acidified by adding 1N hydrochloric acid until a pH of 2.3. The solution is then extracted with ether and the organic layer is washed with water, dried on magnesium sulphate, filtered and evaporated. 82.4 g of 2-cyano 3-(2,6-dichlorophenyl)propanoic acid are obtained.

Provenance & Evidence