HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 86740631, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Chloro-2-(diethylamine)ethane hydrochloride | HCID 13363 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | (+)-cis-2-(4-methoxyphenyl)-3-hydroxy-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one | HCID 15593400 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 86740631 | HCID 86740631 | — |
Reaction Steps
A mixture of 1.01 g of (+)-cis-2-(4-methoxyphenyl)-3-hydroxy-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one, 0.57 g of 2-(diethylamino)ethyl chloride hydrochloride, 1.24 g of potassium carbonate and 30 ml of acetone is treated in the same manner as described in Example 15. The crude product is converted into its fumarate and then recrystallized from ethanol. 1.22 g of (+)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(diethylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one fumarate are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04567175 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-8a5ba1066eb94ebf891902f41676c1d4 |
| Source note | uspto-grants-1986_01 |