Acetic Anhydride → HCID 70453360, compound

HRID 1285356Notes

Reaction equation

HRID 1285356 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@H:9]2[C@@H:15]([OH:16])[C:14](=[O:17])[N:13]([CH2:18][CH2:19][N:20]([CH2:23][CH3:24])[CH2:21][CH3:22])[C:12]3[CH:25]=[CH:26][C:27]([Cl:29])=[CH:28][C:11]=3[S:10]2)=[CH:5][CH:4]=1.[C:30](OC(=O)C)(=[O:32])[CH3:31].[C:37]([O-:42])(=[O:41])[C:38]([O-:40])=[O:39]>N1C=CC=CC=1>[C:37]([OH:42])(=[O:41])[C:38]([OH:40])=[O:39].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C@H:9]2[C@@H:15]([O:16][C:30](=[O:32])[CH3:31])[C:14](=[O:17])[N:13]([CH2:18][CH2:19][N:20]([CH2:23][CH3:24])[CH2:21][CH3:22])[C:12]3[CH:25]=[CH:26][C:27]([Cl:29])=[CH:28][C:11]=3[S:10]2)=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 71081OxalateHCID 70453286HCID 70453286, compound

Product 1

HCID 70453360HCID 70453360, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineCatalyst

Procedure

A mixture of 0.67 g of (+)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(diethylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one, 7 ml of acetic anhydride and 2 drops of pyridine is treated in the same manner as described in Example 16. The crude product is converted into its oxalate and recrystallized from ethanol. 0.634 g of (+)-cis-2-(4-methoxyphenyl)-3-acetoxy-5-[2-(diethylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one oxalate is obtained.

Workup

  1. additionis treated in the same manner
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-eba8ffe574614e4ea5e780ca0de4e1be
Source dataset
uspto-grants-1986_01
Patent number
US04567175

Reaction notes

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