HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 131714504, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 13988138 | HCID 13988138 | — |
| Reactant | Isopropyl alcohol isopropyl ether | HCID 21202047 | — |
| Reactant | HCID 131714505 | HCID 131714505 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 131714504 | HCID 131714504 | 80% |
Reaction Steps
Starting from 9.10 g (22.12 mmol) of BOC-Val-Pro-Pro-OH (X) and 12.30 g (22.12 mmol of HCl.H-Leu-Gly-Trp-Met-OMe (VI) and operating as described in Step 5, but using as an eluant system ethyl acetate containing an increasing amount of methanol from 5 to 30 percent during the chromatographic purification, 16.16 g (80% yield) of compound XI were obtained from iPrOH/iPr2O: m.p. 184°-190° C. [α]D20 =-98.9° (c=1, MeOH); RfB 0.13; RfC 0.58.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04567162 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-774e65a7351d4ca09aa0e04f914dcd67 |
| Source note | uspto-grants-1986_01 |