Dichloromethane → HCID 131714507, compound

Participants

Reaction Steps

Starting from 2.45 g (2.73 mmol) of BOC-Val-Pro-Pro-Leu-Gly-Trp-Met-NH2 (XV) and operating as described in Example 1, Step 6, but using as eluant systems CH2Cl2 :MeOH:H2O=85:15:1 by volume and CH2Cl2 :MeOH:H2O=80:20:1 by volume during the chromatographic purification, 1.55 g (68% yield) of compound XVI were obtained from MeOH/iPrOH/iPr2O after desalting on Sephadex G-10 (Trade Mark): m.p. 150°-158° C.; [α]D24 =-74.8° (c=1, MeOH); RFD 0.36; E1.2 0.55 Glu.

Provenance & Evidence